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Kin-Driver

Batch Information

  • Submitted By: Alex Wagner
  • Submitter Affiliation: McDonnell Genome Institute, Washington University School of Medicine
  • Submission Date: 13-MAY-2016
  • Reference URL: Visit
  • Last Review Date: 13-MAY-2016
  • Total Variants: 103
  • View Variants: Kin-Driver

Justification for Inclusion

Kin-driver is the first database that compiles driver mutations in protein kinases (PKs) with experimental evidence demonstrating their functional role. This expert-curated database determines if a particular mutation has been described in the scientific literature as having activating or inactivating effects. This was achieved through the use of text-mining of PubMed articles for inactivating mutations in tumor-suppressor kinases and gain-of-function mutations in proto-oncogenic kinases, and these were limited to only those mutations with an experimentally demonstrated loss or gain of function. The database presents these variants in their amino acid context, along with an internal representation of associated disease(s) and references. We reviewed their results, selecting transcripts for import into DoCM based upon consistency with the reported amino acid change, the predicted pathogenicity of the mutation, and the existence of primary literature supporting the claim.

Submission Status

Chr Start Stop Ref Var DOID Pubmed Id Status Message
X 100630152 100630152 C T 2583 10352268 included
3 12645687 12645687 G A 3490 17603485 included
3 12645681 12645681 A G 3490 17603482 included
10 43613908 43613908 A T 10017 15753368 included
10 43613908 43613908 A T 0080137 15753368 included
10 43613908 43613908 A T 3973 15753368 included
10 43609948 43609948 T C 0050430 8570194 included
9 27204927 27204927 G C 9119 19340004 included
1 23235518 23235518 G A 9256 18682749 included
7 55242475 55242475 G C 1324 16043828 included
19 1220626 1220626 G A 3852 21816872 included
19 1221995 1221995 C T 3852 12552571 included
19 1223151 1223151 C T 3852 22942091 included
19 1218448 1218448 A G 3852 10353780 included
19 1220433 1220433 G A 3852 9837816 included
4 1806153 1806153 C A 305 19165726 included
4 1803568 1803568 C G 305 10471491 included
4 1807884 1807884 A T 305 9857065 included
4 1803564 1803564 C T 305 10471491 included
4 1807889 1807889 A C 3138 18000903 included
4 1806092 1806092 A T 305 12009017 included
4 1807884 1807884 A C 3138 17875876 included
4 1806099 1806099 A G 305 11429702 included
4 1807889 1807889 A G 305 10471491 included
4 1807889 1807889 A G 305 11429702 included
4 1808331 1808331 G T 305 15880580 included
6 80747723 80747723 G T 1793 20581473 included
4 66270137 66270137 C T 3910 16140923 included
1 65312418 65312418 G T 9952 20167706 included
1 65312347 65312347 C A 12603 19139102 included
11 8457665 8457665 A C 1793 20581473 included
5 149441328 149441328 A C 4960 18971950 included
5 149453044 149453044 A G 2531 2406720 included
5 149433645 149433645 T C 2531 2406720 included
5 149433646 149433646 A G 2531 2406720 included
5 149433645 149433645 T A 2531 2406720 included
5 149453043 149453043 C A 2531 2406720 included
18 18535142 18535142 G A 1612 20140017 included
18 18535142 18535142 G A 1324 20140017 included
9 5078360 5078360 A G 4960 20585391 included
9 5089726 5089726 C A 4960 20585391 included
9 5072541 5072541 G T 4960 17267906 included
9 5073770 5073770 G T 4960 15781101 included
7 55249071 55249071 C T 1324 17332364 included
7 55242470 55242470 T C 1324 16043828 included
17 27062360 27062360 G C 1793 20581473 included
19 1220487 1220487 G A 3910 17676035 included
19 1220629 1220629 C T 3910 17676035 included
19 1218493 1218493 A G 3907 17676035 included
19 1220394 1220394 G T 3907 17676035 included
19 1220487 1220487 G T 1909 10208439 included
19 1223123 1223123 T C 3907 15800014 included
19 1223034 1223034 C T 3852 15800014 included
7 140453179 140453179 C T 162 15035987 included
7 140453134 140453134 T C 162 15035987 included
7 140481402 140481402 C G 162 15035987 included
7 140481417 140481417 C T 162 15035987 included
7 140453136 140453136 A T 162 15035987 included
7 140481417 140481417 C A 162 15035987 included
7 140453150 140453150 A C 162 15035987 included
7 140453139 140453139 G A 162 15035987 included
7 140453146 140453146 G C 162 15035987 included
7 140481402 140481402 C A 162 15035987 included
2 29432664 29432664 C T 769 18923523 included
2 29432664 29432664 C T 769 21242967 included
2 29443697 29443697 A G 769 18923523 included
2 29443697 29443697 A G 769 2124297 included
2 29436860 29436860 A G 769 18990089 included
2 29432655 29432655 T G 769 18923523 included
2 29436860 29436860 A T 769 18990089 included
2 29443696 29443696 A C 769 18923523 included
2 29445228 29445228 A C 769 18724359 included
2 29445213 29445213 A T 769 18724359 included
2 29443697 29443697 A T 769 18990089 included
2 29445450 29445450 C G 769 18724359 included
2 29443697 29443697 A C 769 18923523 included
19 17945717 17945717 C T 627 18559588 included
19 17945696 17945696 C T 8761 16843266 included
19 17954215 17954215 G T 8761 16843266 included
19 17945969 17945969 C T 3166 18397343 included
19 17948009 17948009 G A 8761 16843266 included
19 17949138 17949138 C A 3166 18397343 included
19 17954634 17954634 A G 3166 18397343 included
13 28608276 28608276 A G 9119 16410449 included
13 28608320 28608320 A G 9119 16410449 included
13 28592642 28592642 C T 9119 16573742 included
13 28592637 28592637 G C 9119 19840437 included
13 28602340 28602340 G T 9119 16150941 included
13 28592638 28592638 A C 9119 14737077 included
13 28592622 28592622 G T 9119 15625552 included
13 28592641 28592641 T G 9119 16213360 included
13 28592639 28592639 T G 9119 15863200 included
13 28608284 28608284 T C 9119 16091740 included
13 28592642 28592642 C G 9119 14737077 included
13 28592639 28592639 T C 9119 16573742 included
13 28608281 28608281 A G 9119 16410449 included
13 28592639 28592639 T A 9119 16371029 included
13 28592640 28592640 A T 9119 19603346 included
13 28592624 28592624 T G 9119 16990784 included
13 28592641 28592641 T A 9119 16371029 included
13 28602381 28602381 T G 9119 16990784 included
13 28592629 28592629 T C 9119 16990784 included
13 28592642 28592642 C A 9119 15178581 included
10 123247519 123247519 T C 2871 17525745 included
10 123274797 123274797 T C 2871 17525745 included
10 123279677 123279677 G C 12960 10851026 included
10 123258039 123258039 T G 2871 17525745 included
10 123247517 123247517 T A 2871 17525745 included
10 123247577 123247577 A T 2871 17525745 included
10 43609096 43609096 T C 10017 10490816 included
10 43609096 43609096 T C 0050430 10490816 included
10 43609096 43609096 T C 10016 10490816 included
10 43609096 43609096 T C 0080137 10490816 included
10 43609096 43609096 T C 3973 10490816 included
10 43609950 43609950 C G 10017 8570194 included
10 43609950 43609950 C G 0050430 8570194 included
10 43609950 43609950 C G 10016 8570194 included
10 43609950 43609950 C G 0080137 8570194 included
10 43609950 43609950 C G 3973 8570194 included
10 43609936 43609936 T C 10017 10490816 included
10 43609936 43609936 T C 0050430 10490816 included
10 43609936 43609936 T C 10016 10490816 included
10 43609936 43609936 T C 0080137 10490816 included
10 43609936 43609936 T C 3973 10490816 included
10 43613840 43613840 G C 10017 9242375 included
10 43613840 43613840 G C 0050430 9242375 included
10 43613840 43613840 G C 10016 9242375 included
10 43613840 43613840 G C 0080137 9242375 included
10 43613840 43613840 G C 3973 9242375 included
10 43609097 43609097 G A 10017 10490816 included
10 43609097 43609097 G A 0050430 10490816 included
10 43609097 43609097 G A 10016 10490816 included
10 43609097 43609097 G A 0080137 10490816 included
10 43609097 43609097 G A 3973 10490816 included
10 43609070 43609070 G A 10017 10490816 included
10 43609070 43609070 G A 0050430 10490816 included
10 43609070 43609070 G A 10016 10490816 included
10 43609070 43609070 G A 0080137 10490816 included
10 43609070 43609070 G A 3973 10490816 included
10 43617416 43617416 T C 10017 8570194 included
10 43617416 43617416 T C 0050430 8570194 included
10 43617416 43617416 T C 10016 8570194 included
10 43617416 43617416 T C 0080137 8570194 included
10 43617416 43617416 T C 3973 8570194 included
10 43613908 43613908 A T 0050430 15753368 included
10 43613908 43613908 A T 10016 15753368 included
10 43609948 43609948 T C 10017 8570194 included
10 43609948 43609948 T C 10016 8570194 included
10 43609948 43609948 T C 0080137 8570194 included
10 43609948 43609948 T C 3973 8570194 included
10 43609949 43609949 G A 10017 8570194 included
10 43609949 43609949 G A 0050430 8570194 included
10 43609949 43609949 G A 10016 8570194 included
10 43609949 43609949 G A 0080137 8570194 included
10 43609949 43609949 G A 3973 8570194 included
10 43615568 43615569 GC TT 10017 10445857 included
10 43615568 43615569 GC TT 0050430 10445857 included
10 43615568 43615569 GC TT 10016 10445857 included
10 43615568 43615569 GC TT 0080137 10445857 included
10 43615568 43615569 GC TT 3973 10445857 included
17 37881378 37881378 A G 3713 18339846 included
17 37880997 37880997 G A 3717 18339846 included
7 116423407 116423407 G C 305 9826708 included
7 116423428 116423428 T G 305 12460923 included
7 116423413 116423413 T C 305 9826708 included
7 116417457 116417457 G A 305 10417759 included
7 116417481 116417481 A T 305 12460923 included
7 116423474 116423474 T C 305 9826708 included
7 116411990 116411990 C T 305 1104268 included
7 116423414 116423414 A G 305 9826708 included
4 55593661 55593661 T C 9253 16731599 included
4 55599321 55599321 A T 2531 16731599 included
4 55593610 55593610 T C 9253 16731599 included
4 55593613 55593613 T A 9253 16731599 included
4 55593606 55593606 A C 9253 16731599 included
4 55593604 55593604 G C 9253 16731599 included
4 55594221 55594221 A G 2531 11526490 included
4 55593613 55593613 T G 9253 16731599 included
4 55593603 55593603 T G 9253 16731599 included
4 55593610 55593610 T G 9253 16731599 included
4 55593608 55593608 G T 9253 16731599 included
4 55599320 55599320 G C 2531 16731599 included
4 55593610 55593610 T A 9253 16731599 included
4 55593606 55593606 A G 9253 16731599 included
4 55593603 55593603 T A 9253 16731599 included
4 55593605 55593605 G C 9253 16731599 included
4 55593613 55593614 TT AA 9253 16731599 included
4 55599320 55599320 G T 2531 16731599 included
4 55593604 55593605 GG TT 9253 16731599 included
3 12626123 12626123 G C 3490 17603482 included
3 12626123 12626123 G C 3490 17603489 included
3 12645699 12645699 G A 3490 17603482 included
3 12645699 12645699 G A 3490 1760348 included
3 12645693 12645693 G A 3490 17603482 included
3 12645693 12645693 G A 3490 17603484 included
5 176520181 176520181 A G 1612 19946327 included
5 176522552 176522552 T A 3247 19809159 included
1 16458722 16458722 C T 13574 19649315 included
1 16464489 16464489 C T 3907 20360610 included
19 1207168 1207168 C G 3907 17676035 included
19 1220437 1220437 T A 3852 12552571 included
19 1222987 1222987 G C 3852 9837816 included
19 1207112 1207112 T C 3852 9837816 included
19 1220699 1220699 G C 3852 12372054 included
2 29443642 29443642 C G 769 18724359 included
2 29432739 29432739 A G 769 18724359 included
22 29091774 29091774 C A 1612 17721994 included
22 29092944 29092944 T G 1612 22114986 included
13 28608285 28608285 A C 9119 16091740 included
10 123258111 123258111 T C 2340 17803937 included
10 123256215 123256215 T G 2340 17803937 included
10 123247578 123247578 T G 2340 17803937 included
10 123276892 123276892 C T 2339 10851026 included
10 43615592 43615592 T G 10017 15753368 included
10 43615592 43615592 T G 0050430 15753368 included
10 43615592 43615592 T G 10016 15753368 included
10 43615592 43615592 T G 0080137 15753368 included
10 43615592 43615592 T G 3973 15753368 included
10 43614996 43614996 G C 10017 9242375 included
10 43614996 43614996 G C 0050430 9242375 included
10 43614996 43614996 G C 10016 9242375 included
10 43614996 43614996 G C 0080137 9242375 included
10 43614996 43614996 G C 3973 9242375 included
10 43609103 43609103 G A 10017 9012462 included
10 43609103 43609103 G A 0050430 9012462 included
10 43609103 43609103 G A 10016 9012462 included
10 43609103 43609103 G A 0080137 9012462 included
10 43609103 43609103 G A 3973 9012462 included
7 116423407 116423407 G A 305 9826708 included
3 12645688 12645688 G A 3490 17603482 included
3 12645688 12645688 G A 3490 17603487 included
3 12645688 12645688 G C 3490 17603482 included
3 12645688 12645688 G C 3490 17603486 included
3 12645687 12645687 G A 3490 17603482 included
3 12627244 12627244 G A 3490 17603482 included
3 12627244 12627244 G A 3490 17603489 included
3 12645681 12645681 A G 3490 17603488 included
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